人物简介

姓名：水雯箐

性别：女

职称：副教授

所属部门：生物化学和分子生物学系

学历：

2010年5月至今 南开大学生命科学学院 副教授

2009年至2010年 美国Thermo Fisher Scientific 生物技术公司 应用科学家

2004年至2008年 美国加州大学伯克利分校化学系 化学博士

1998年至2004年 中国上海复旦大学化学系 化学学士和硕士

研究方向

1）发展和应用新型的生物质谱技术用于鉴定蛋白质翻译后修饰（例如磷酸化、乙酰化、糖基化等），考察特定的修饰基团在细胞状态转变过程中特异性的变化，从而鉴定与该生物过程直接相关的修饰位点；

2）研究蛋白质特定的翻译后修饰对多潜能性干细胞的诱导和分化，以及病毒-宿主细胞的相互作用产生如何的影响；

3）发展和应用新型的生物质谱技术研究蛋白质-蛋白质、蛋白质-配体形成的复合物的结构信息。

论文发表

1.Shui, W.*; Lin, S.; Zhang, A.; Chen, Y.; Huang, Y.; Sanders, M. “Driving efficiency in a high-throughput metabolic stability assay through a generic high-resolution accurate mass method and automated data mining” Protein Cell 2011, 8, 680-688. (correspondence)

2.Guo, Y.; Wang, J.; Niu, G.; Shui, W.; Sun, Y.; Zhou, H.; Zhang, Y.; Yang, C.; Lou, Z.; Rao, Z. “A structural view of the antibiotic degradation enzyme NDM-1 from a superbug” Protein Cell 2011, 5, 384-394.

3.Shui, W.*; Petzold, C.; Redding, A.; Liu, J.; Pitcher, A.; Keasling, J.; Bertozzi, C. “Organelle Membrane Proteomics Reveals New Insights on Phagosome Maturation Mediated by Mycobacterial Lipoglycans” Journal of Proteome Research 2011, 10, 339-348. (co-correspondence)

4.Shui, W.; Gilmore, S.; Sheu, L; Liu, J.; Keasling, J.; Bertozzi, C. “Quantitative Proteomic Profiling of Host-Pathogen Interactions: The Macrophage Response to Mycobacterium tuberculosis Lipids” Journal of Proteome Research 2009, 8, 282-289.

5.Wu, P.; Shui, W.; Carlson, B.; Bertozzi, C. “Site-specific chemical modification of recombinant proteins produced in mammalian cells using the genetically-encoded aldehyde tag” Proceedings of the National Academy of Sciences 2009, 106, 3000-3005.

6.Tang, Y.*; Shui, W.*; Myers, S.; Kang, Y.; Ouellet, M.; Bertozzi, C.; Keasling, J. “Central Metabolism and Hypoxic Response of Mycobacterium smegmatis Studied by Isotopomer Labeling” Biotechnology Letter 2009, 31, 1233-1240.(co-first)

7.Shui W.; Sheu, L.; Liu, J.; Smart, B.; Keasling, J.; Bertozzi, C. “Membrane Proteomics of Phagosomes Suggests a Connection to Autophagy” Proceedings of the National Academy of Sciences 2008, 105, 16952-16957.

8.Shui, W.; Fan, J.; Yang, P.; Liu, C.; Zhai, J.; Lei, J.; Yan, Y.; Zhao, D.; Chen, X. “Nanopore-based proteolytic reactor for sensitive and comprehensive proteomic analyses” Analytical Chemistry 2006, 78, 4811-4819.

9.Shui, W.; Liu, Y.; Fan, H.; Bao, H.; Liang, S.; Yang, P.; Chen, X.“ Enhancing TOF/TOF-based de novo sequencing capability for high throughput protein identification with amino acid-coded mass tagging” Journal of Proteome Research 2005, 4, 83-90.

10.Fan, J.*; Shui, W.*; Yang, P.; Wang, X.; Xu, Y.; Wang, H.; Chen, X.; Zhao, D. “Mesoporous silica nanoreactors for highly efficient proteolysis” Chemistry-A European Journal 2005, 11, 5391-5396.(co-first)

11.Zhai, J.; Shui, W.; Xu, X.; Yu, Y.; Bao, H.; Chen, X.; Yang, P. “A modified nanospray tip coupled to a mass spectrometer for analyzing enzymatic peptides” Rapid Communications in Mass Spectrometry 2004, 18, 1177-1179.

12.Shui, W.; Yu, Y.; Xu, X.; Huang, Z.; Xu, G.; Yang, P. “Micro-electrospray with stainless steel emitters” Rapid Communications in Mass Spectrometry 2003, 17, 1541-1547.

13.Wei, J.; Shui, W.; Zhou, F.; Lu, Y.; Chen, K.; Xu, G.; Yang, P. “Naturally and externally pulsed electrospray” Mass Spectrometry Review 2002, 21, 48-162.